Suppressor of cytokine signaling 1 (SOCS1), also known as Jak-binding protein (JAB) and Tec-interacting protein 3 (TIP3), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.

Optimal dilution of the TIP3 antibody should be determined by the researcher.

Amino acids FLVRDSRQRNCFFALSVKMA were used as the immunogen for the TIP3 antibody.

After reconstitution, the TIP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.